Treatment of rheumatoid arthritis by Dr.Rashid Iqbal MBBS MD скачать в хорошем качестве

Treatment of rheumatoid arthritis by Dr.Rashid Iqbal MBBS MD

In this comprehensive Pharmacology lecture, we discuss the Treatment of Rheumatoid Arthritis (RA) in a structured, clinical, and exam-oriented manner. This topic is highly important for MBBS, BDS, Nursing, Pharmacy, NEET PG, USMLE, and other competitive exams. 🔹 Introduction to Rheumatoid Arthritis • Definition of RA • Autoimmune inflammatory joint disease • Chronic, progressive, systemic involvement 🔹 Normal vs Arthritic Joint • Normal synovial membrane • Synovial inflammation in RA • Pannus formation • Cartilage destruction • Joint deformity 🔹 Criteria for Classification • Clinical features • Serology (RF, Anti-CCP) • Acute phase reactants • Duration of symptoms 🔹 Goals of Management • Reduce inflammation • Prevent joint damage • Preserve joint function • Improve quality of life • Achieve remission or low disease activity 🔹 Management of Rheumatoid Arthritis ✅ Non-Pharmacological Management • Patient education • Physiotherapy • Exercise • Lifestyle modification • Joint protection ✅ Pharmacological Management 1️⃣ Glucocorticoids • Used for rapid symptom control • Bridge therapy • Anti-inflammatory & immunosuppressive action 2️⃣ DMARDs (Disease Modifying Anti-Rheumatic Drugs) These are the mainstay of RA treatment. 🔸 Methotrexate • Drug of choice • Inhibits folate pathway • First-line DMARD 🔸 Leflunomide • Inhibits pyrimidine synthesis • Alternative to methotrexate 🔸 Cyclosporine • Calcineurin inhibitor • Suppresses T-cell activation 🔸 Azathioprine • Purine synthesis inhibitor • Immunosuppressant 🔸 Penicillamine • Older DMARD • Rarely used due to toxicity 🔸 Hydroxychloroquine • Antimalarial drug • Used in mild RA rheumatoid arthritis treatment, RA pharmacology lecture, DMARD drugs, methotrexate pharmacology, leflunomide mechanism, hydroxychloroquine uses, azathioprine pharmacology, cyclosporine mechanism, glucocorticoids in RA, rheumatoid arthritis management, autoimmune arthritis treatment, MBBS pharmacology, NEET PG pharmacology, USMLE pharmacology, inflammatory arthritis drugs 📚 This lecture clearly explains: • Mechanism of joint destruction • Stepwise management • Role of steroids • Importance of DMARDs • Drug of choice in RA • High-yield exam points If you found this helpful, like, share, and subscribe for more pharmacology lectures. #RheumatoidArthritis #DMARD #Methotrexate #Pharmacology #AutoimmuneDisease #MedicalStudents #MBBS #NEETPG #USMLE #Glucocorticoids