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Underlying causes of

THIRTY SEVEN: Welcome to Episode 27 of The Long COVID Clinic’s Fireside Chat Series with Dr Binita Kane and Helen Oakleigh. Title: Underlying causes of ME - a unifying hypothesis? YouTube Live: 18:00 GMT 19:00 CET (Amsterdam, Berlin, Paris, Rome, Madrid) 18:00 WET (Lisbon) 20:00 EET (Athens, Bucharest, Helsinki) Dr Kane speaks with Dr Klaus Wirth, who, together with Professor Carmen Scheibenbogen, has conducted groundbreaking research into the underlying biology of ME/CFS—work that may help pave the way for future treatments. In this discussion, Dr Wirth explains evidence for autoantibodies targeting receptors that regulate blood vessel dilation in people with ME. He outlines how impaired blood flow to muscles and tissues can trigger compensatory processes leading to excess sodium and calcium inside cells, resulting in mitochondrial damage and autonomic dysfunction. This work supports a potentially unifying hypothesis for muscle dysfunction in ME/CFS and in many people with Long COVID and offers a potential explanation for core symptoms such as post-exertional malaise. About the Panel: Our Guest, Prof. Dr. Klaus Wirth: Prof. Dr. Klaus Wirth is a German physician, pharmacologist, and biotech entrepreneur with decades of experience spanning academic medicine and the pharmaceutical industry. He is a Professor of Pharmacology at Goethe University Frankfurt and CSO and Co-Founder of Mitodicure GmbH, where he focuses on translational approaches to muscle and mitochondrial dysfunction. Since 2018, Prof. Wirth has been a leading contributor to ME/CFS and Long COVID research, co-authoring influential papers that link vascular, immunological, and skeletal muscle pathophysiology to post-exertional malaise. He also treats patients with ME/CFS and continues to bridge mechanistic science with therapeutic innovation. Dr Binita Kane: Consultant respiratory physician; founder of The Long COVID Clinic. Leads a multidisciplinary team delivering assessment and evidence-informed rehabilitation for adults and children, with a strong focus on patient safety. One of the few Long COVID services actively translating research into positive practice. Helen Oakleigh: Filmmaker, writer and founding member of Long Covid Support; co-host ensuring the science stays clear and understood. Hashtags: #LongCOVID #MECFS #Mitochondria #ExerciseIntolerance #PEM #POTS #Dysautonomia #Deconditioning #Fatigue #Pacing #SaltAndHydration #DrBinitaKane #KlausWirth #HelenOakleigh #FiresideChat #LongCOVIDClinic Channel Tags: @LCCWYCD @longcovidsupport @DysautonomiaInternational @openmedf @MayoClinic @ClevelandClinic @UCSF @YaleMedicine @StanfordMedicine @MedCram @batemanhornecenter @TheLongCOVIDClinic @BinitaKane @HelenOakleigh Relevant Links Prof Klaus Wirth https://mitodicure.com https://events.mecfs-research.org   / en   https://pubmed.ncbi.nlm.nih.gov/39727... https://link.springer.com/article/10.... https://www.mdpi.com/1648-9144/58/12/... https://x.com/mitodicure Dr Binita Kane Linktree: https://linktr.ee/binitakane Website: https://thelongcovidclinic.co.uk/ Educational content only; not medical advice. If unwell, stop and seek medical help. Emergencies: call 999.