Synthesis Workshop: Total Synthesis of Azitine with Dr. Jie Liu (Episode 89) скачать в хорошем качестве

Synthesis Workshop: Total Synthesis of Azitine with Dr. Jie Liu (Episode 89)

In this Research Spotlight episode, Dr. Jie Liu joins us to share his work on the total synthesis of azitine and the proposed structure of navirine C. Key reference: Angew. Chem. Int. Ed. 2018, 57, 6676-6680. http://doi.org/10.1002/anie.201803018 Other references (in order of appearance): Nat. Prod. Rep. 2010, 27, 529-570. Key advances: Nature 2015, 528, 493-498; Nat. Commun. 2016, 7, 12183; Angew. Chem. Int. Ed. 2016, 55, 15667-15671; Angew. Chem. Int. Ed. 2016, 55, 392-396; J. Am. Chem. Soc. 2016, 138, 10830-10833; J. Am. Chem. Soc. 2017, 139, 13882-13896; Angew. Chem. Int. Ed. 2018, 57, 937-941; J. Am. Chem. Soc. 2018, 140, 9025-9029. Chelation-controlled conjugate additions: Org. Lett. 2000, 2, 1477– 1479. Sulfonylmethyl isocyanides: J. Org. Chem. 1977, 42, 3114– 3118; oxidative dearomatization/Diels-Alder cascade: Org. Biomol. Chem. 2012, 10, 1411– 1417; Nat. Prod. Rep. 2017, 34, 1044-1050. Also see: J. Org. Chem. 2014, 79, 6783– 6800. HAT-mediated cyclizations with nitriles: Chem. Eur. J. 2018, 24, 18658-18662.