Conquering ALS: My Journey to Challenge the Mission lmpossible | lei cai | TEDxShanghai скачать в хорошем качестве

Conquering ALS: My Journey to Challenge the Mission lmpossible | lei cai | TEDxShanghai

Amyotrophic lateral sclerosis (ALS) warrior Cai Lei: China's "Don Quixote," challenging invisible windmills. Cai Lei is a fighter against amyotrophic lateral sclerosis (ALS) and a serial entrepreneur who has served as a senior executive in large corporate groups. After being diagnosed with ALS, Cai Lei initiated a series of world-shocking actions to combat ALS over a period of more than four years: he established the world's largest ALS research data platform centered on patients' full life cycle, connecting over ten thousand patients; he led and called for the voluntary donation of bodies and spinal cord tissues from thousands of people, driving the establishment of China's ALS pathology research sample bank from scratch; he collaborated with BGI Group and the Supercomputing Center of the Chinese Academy of Sciences to construct and analyze a large-scale open gene bank for ALS patients, achieving new discoveries in genetic causation research; he established large-scale research sample platforms including patient blood and cerebrospinal fluid proteomics, metabolomics, hair heavy metal analysis, iPSC differentiation into motor neurons, ALS-like organs, etc.; Cai Lei's team accelerated pre-clinical and clinical trials rapidly through data systems and collaboration with various parties, and has developed and promoted over a hundred ALS drug pipelines. Cai Lei is also a promoter of electronic invoices in China, the author of the bestselling book "Believe" with two million copies sold, the initiator of the second Ice Bucket Challenge, the founder of the ALS Charitable Trust, and the founder of the "Cai Lei Breaking Ice Relay Station" live e-commerce platform. Through this entrepreneurial endeavor of "challenging the impossible," he has not only brought hope for life-saving treatment to half a million ALS patients but also conveyed warmth and inspiring power to people in distress. 蔡磊是渐冻症抗争者，也是一名连续创业者，曾长期担任大型集团企业高管。蔡磊在确诊渐冻症后，在四年多的时间里发起了一系列震惊世界的攻克渐冻症行动：他建立了世界最大的以患者为中心360度全生命周期的渐冻症科研数据平台，并链接了超过一万名患者；带头并呼吁千人志愿遗体和脑脊髓组织捐献，从0到1推动建立了中国的渐冻症病理科研样本库；携手华大集团、中科院超算中心进行渐冻症患者规模化开放基因库建设和分析，目前已经实现基因层面病因研究的新发现；建立大规模的患者血液和脑脊液蛋白组学、代谢组学、毛发重金属分析、iPSC分化运动神经元、ALS类器官等科研样本平台；蔡磊团队通过数据系统和携手各方极速加快了临床前和临床试验，目前已研发和合作推动了一百多条渐冻症药物管线。 蔡磊是中国电子发票推动者，两百万册畅销书《相信》作者，第二次冰桶挑战发起人，攻克渐冻症慈善信托创立者，“蔡磊破冰驿站”直播电商平台创始人。他通过这场“挑战不可能”的创业，不仅为五十万渐冻症病友带来生命救治的希望，也给身处困境中的人们传递了温暖和鼓舞人心的力量。 This talk was given at a TEDx event using the TED conference format but independently organized by a local community. Learn more at https://www.ted.com/tedx