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#coffee #caffiene #immunesystem #research #news A recent pilot study published in the European Journal of Nutrition explored whether coffee has different short-term effects on the immune system compared to pure caffeine. Coffee and caffeine are widely consumed and studied for their potential metabolic and immunological effects, but coffee is a complex mixture of bioactive compounds—not just caffeine. Understanding how these components interact in the body is important, especially since coffee is a common dietary exposure rather than a medical treatment. The randomized crossover study involved 10 healthy adults aged 20 to 40 years who were regular coffee drinkers. On separate occasions, participants consumed coffee, a caffeine solution containing an equivalent dose (approximately 130 mg), or water as a control. All beverages were taken after a standardized meal to minimize variations in post-meal metabolic responses. Washout periods were included between sessions to avoid carryover effects. Researchers measured circulating inflammatory markers, including interferon-gamma and selected interleukins, as well as caffeine levels in the blood. The findings showed modest but noticeable differences between coffee and pure caffeine. The caffeine solution produced a stronger short-term suppression of certain inflammatory cytokines compared to coffee. In contrast, coffee often triggered immune responses that were closer to those seen with water, despite containing the same amount of caffeine. This suggests that other components in coffee, such as polyphenols and other bioactive compounds, may influence or modify caffeine’s immunological effects. Interestingly, blood caffeine exposure was slightly higher after consuming coffee than after the caffeine solution, indicating that the coffee “matrix” may affect caffeine absorption or metabolism. However, the authors cautioned that this was a small pilot study, and such findings should be interpreted carefully. Importantly, all immune changes were temporary and mild, with no clinically significant adverse effects observed. Overall, the study suggests that coffee is not simply equivalent to isolated caffeine in terms of short-term immune responses. Check full updates on Medical Dialogues Also check out - Medical Dialogues Academy, a renowned academic wing of Medical Dialogues - India's premier health and news online portal, proudly presents this comprehensive course tailored for healthcare professionals eager to delve into the realm of medical journalism. 🔗 Enroll Today: https://academy.medicaldialogues.in/c... 📚 Explore More With Us: 📌 Medical Content Writing: https://academy.medicaldialogues.in/c... 📌 Certificate Course in Pharmaceutical Medico-Marketing: https://academy.medicaldialogues.in/c... Join us on this enlightening journey and become a part of a community pushing the boundaries of healthcare communication and reporting. Get the latest medical and health news at medicaldialogues.in Follow us on Twitter: / medicaldialogs Facebook: / medicaldialogues Instagram: / medicaldialogues LinkedIn: / medical-dialogues Website: https://medicaldialogues.in/