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Chemistry professor Stephen Fried provides a brief overview of the protein folding process and the role of the "misfolded" state in neurodegenerative diseases like Alzheimer's and Parkinson's. The Fried Lab is interested in asking a fundamental question of which proteins are good at following the rules and folding correctly and which ones are more prone to forming misfolded states. Can molecules be designed that intercept the misfolded proteins and prevent them from forming aggregates that go on to be associated with neurodegenerative diseases? The Fried Lab research focuses on ➜ Unraveling the biophysical basis behind how cells fold and assemble complex protein architectures. ➜ Developing tools to watch proteins fold on the ribosome in their native cellular context. ➜ Applying our understanding of protein (mis-)folding to treat diseases, such as Alzheimer's and Parkinson's. ➜ Teaching cells to build useful new protein materials for us. // FIND OUT MORE ➜ Stephen Fried Lab website: https://friedlab.com/research/ ➜ Johns Hopkins University chemistry department: https://chemistry.jhu.edu/ //SUBSCRIBE ➜ / jhuartssciences //FOLLOW US ➜ Twitter: / jhuartssciences ➜ Instagram: / jhuartssciences ➜ TikTok: / jhuartssciences ➜ Facebook: / jhuartssciences ➜ Our website: https://krieger.jhu.edu #jhuartssciences #johnshopkinsuniversity #research