Endocrinology | Adrenal Medulla | Catecholamines скачать в хорошем качестве

Endocrinology | Adrenal Medulla | Catecholamines

Official Ninja Nerd Website: https://ninjanerd.org Ninja Nerds! In this endocrine physiology lecture, Professor Zach Murphy explores the adrenal medulla, the neuroendocrine center responsible for producing and releasing catecholamines, including epinephrine and norepinephrine. This lecture emphasizes how the adrenal medulla bridges the nervous and endocrine systems to mount rapid, life-saving responses during acute stress. We begin with the embryologic origin of the adrenal medulla from neural crest cells and its functional innervation by preganglionic sympathetic neurons. You’ll learn how acetylcholine stimulates chromaffin cells to secrete catecholamines directly into the bloodstream, initiating the “fight or flight” response. The lecture breaks down the biosynthesis pathway of catecholamines from tyrosine, the differential release of epinephrine vs. norepinephrine, and the role of phenylethanolamine-N-methyltransferase (PNMT)—an enzyme upregulated by cortisol from the adrenal cortex. We also cover the adrenergic receptor subtypes (α and β receptors) and how they mediate diverse physiologic effects on the heart, vasculature, lungs, liver, and more. Enjoy the lecture and support us below! 🌐 Official Links Website: https://www.ninjanerd.org Podcast: https://podcast.ninjanerd.org Store: https://merch.ninjanerd.org 📱 Social Media   / ninjanerdlectures     / ninjanerdlectures     / ninjanerdlectures   https://x.com/ninjanerdsci/   / ninja-nerd   💬 Join Our Community Discord:   / discord   #ninjanerd #Catecholamines #AdrenalMedulla