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Is obesity a genetic disease? The answer is more complex than a simple “yes” or “no.” In this video, we discuss research exploring the Carbohydrate Insulin Model using Mendelian Randomization to reveal how genetics can influence your body’s response to carbs, impacting fat storage. We will break down the science and conclude on practical takeaways for precision nutrition. Discover how your genetic predisposition can guide your diet choices and why understanding this interplay between genetics, insulin, and diet could revolutionize obesity management. Astley CM et al. Genetic Evidence That Carbohydrate-Stimulated Insulin Secretion Leads to Obesity. Clinical Chemistry. 2018 For other references and a written walkthrough, see my newsletter: https://staycuriousmetabolism.substac... Chapters – 0:00 – Is Obesity a Genetic Disease? 1:26 – Mendelian Randomization to Assess Carbohydrate Insulin Model 1:39 – What is the Carbohydrate Insulin Model? 3:24 – What is Mendelian Randomization? 3:59 – Study Methods 5:40 – Carb-stimulated Insulin Release Predicts Higher BMI 6:36 – Quick Mechanism Summary 6:54 – Bidirectional Mendelian Randomization 7:56 – Practical Takeaways 9:16 – Enables Precision Nutrition Approach 9:48 – Study Limitation #obesity #genetics #personalizednutrition #insulinresistance #lowcarb #metabolism #metabolichealth #staycurious