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Reaching age 60 without developing certain chronic diseases is a significant indicator of longevity and can strongly predict the likelihood of living to 100 years or beyond. The first critical disease to avoid is cardiovascular disease, including heart attack, stroke, and heart failure, as heart disease remains the leading cause of death globally and its absence at 60 indicates excellent cardiovascular health. The second condition is type 2 diabetes, which accelerates aging through damage to blood vessels, nerves, and organs, so reaching 60 without insulin resistance or diabetes is a strong predictor of longevity. The third disease to avoid is cancer, particularly common types like lung, breast, colon, or prostate cancer, as the absence of cancer at 60 suggests a robust immune system and good lifestyle habits. The fourth condition is chronic obstructive pulmonary disease (COPD) or other chronic respiratory diseases, often caused by smoking or environmental exposure, which significantly compromise quality and length of life. The fifth disease is dementia or significant cognitive decline, as maintaining cognitive function at 60 is strongly correlated with longevity and quality of life in subsequent years. Studies of centenarians show that those who live to 100 typically avoided these five major disease categories through a combination of favorable genetics, healthy lifestyle, balanced diet, regular exercise, abstinence from smoking, and effective stress management. It's important to note that while the absence of these diseases significantly increases chances of longevity, other factors such as social support, purpose in life, and maintaining physical and mental activity continue to be crucial in the following years.