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What Happens to Your Body On Creatine | Science Explained In this Science Explained video, we examine what happens to your body when you take creatine. Learn how creatine affects muscle energy production, strength, hydration, and overall physical performance. Creatine plays a direct role in cellular energy systems by supporting ATP regeneration, particularly in muscle and nerve cells. This video explains how creatine supplementation influences short-term power output, training capacity, and water distribution inside muscle tissue, as well as why these effects occur at the cellular level. We also explore how creatine may affect recovery, fatigue resistance, and body weight changes, and address common concerns related to kidney function, hydration, and long-term use. The video explains what science actually shows about creatine’s benefits, limitations, and safety when used appropriately. Discover: • How creatine supports ATP and muscle energy • Why strength and performance may increase • Changes in muscle hydration and cell volume • Effects on recovery and fatigue • Common misconceptions about creatine and kidney health • What science says about long-term creatine use Understanding how creatine works in the body can help you make informed decisions about supplementation and performance-focused nutrition. 📚 Sources: Wallimann, T., Tokarska-Schlattner, M., & Schlattner, U. (2011). "The Creatine Kinase System and Pleiotropic Effects of Creatine." Amino Acids, 40(5), 1271-1296. Sahlin, K. (2014). "Muscle Energetics During Explosive Activities and Potential Effects of Nutrition and Training." Sports Medicine, 44(Suppl 2), 167-173. Häussinger, D., Roth, E., Lang, F., & Gerok, W. (1993). "Cellular Hydration State: An Important Determinant of Protein Catabolism in Health and Disease." The Lancet, 341(8856), 1330-1332. Safdar, A., et al. (2008). "Global Gene Expression Profiling of Skeletal Muscle in Response to Short-Term Creatine Monohydrate Supplementation." Physiological Genomics, 32(2), 219-228. Rae, C., Digney, A.L., McEwan, S.R., & Bates, T.C. (2003). "Oral Creatine Monohydrate Supplementation Improves Brain Performance: A Double-Blind, Placebo-Controlled, Cross-Over Trial." Proceedings of the Royal Society of London. Series B: Biological Sciences, 270(1529), 2147-2150. Kondo, D.G., et al. (2011). "Open-Label Adjunctive Creatine for Female Adolescents with SSRI-Resistant Major Depressive Disorder." Journal of Clinical Psychiatry, 72(7), 917-921. Brosnan, J.T., da Silva, R.P., & Brosnan, M.E. (2011). "The Metabolic Burden of Creatine Synthesis." Amino Acids, 40(5), 1325-1331. Stead, L.M., Brosnan, J.T., Brosnan, M.E., et al. (2006). "Methylation Demand for Creatine Synthesis in Man." American Journal of Physiology-Endocrinology and Metabolism, 291, E1017–E1023. Olsen, S., Aagaard, P., Kadi, F., Tufekovic, G., Verney, J., Olesen, J.L., Suetta, C., & Kjaer, M. (2006). "Creatine Supplementation Augments the Increase in Satellite Cell and Myonuclei Number in Human Skeletal Muscle Induced by Strength Training." The Journal of Physiology, 573(2), 525-534. Burke, D.G., et al. (2008). "Effect of Creatine Supplementation and Resistance-Exercise Training on Muscle Insulin-Like Growth Factor in Young Adults." International Journal of Sport Nutrition and Exercise Metabolism, 18(4), 389-398. van der Merwe, J., Brooks, N.E., & Myburgh, K.H. (2009). "Three Weeks of Creatine Monohydrate Supplementation Affects Dihydrotestosterone to Testosterone Ratio in College-Aged Rugby Players." Clinical Journal of Sport Medicine, 19(5), 399-404. Kreider, R.B., et al. (2017). "International Society of Sports Nutrition Position Stand: Safety and Efficacy of Creatine Supplementation in Exercise, Sport, and Medicine." Journal of the International Society of Sports Nutrition, 14, 18. 🔔 Like, subscribe, and share to learn how supplements affect your body through real science. 💬 Comment below: Have you ever used creatine, or are you considering it? #scienceexplains #kidney #fasting #healthscience explains #health #healthysciencestickman #creatine #supplements #musclehealth #PerformanceScience