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Join Brandon and Dr. Richard LaFountain from the Healthspan clinical team as they dive deeper into the topic of fructose in this informative episode. Building on the introductory 'Fructose 1.0,' they explore recent research on endogenous fructose production and its health implications. Understand the role of the polyol pathway, uric acid production, and the impact of dietary choices on metabolic health. They also discuss how beta-hydroxybutyrate (BHB) from ketogenic diets may mitigate some of the negative effects of high uric acid. 00:00 Introduction and Welcome 00:24 Deep Dive into Fructose 2.0 00:43 Introducing Dr. Richard LA 02:14 Fructose Controversy and Health Implications 04:03 Upcoming Debate: Dr. Rick Johnson vs. Dr. Lane Norton 07:10 Recap of Fructose 1.0 09:00 Endogenous Fructose Production 11:29 Polyol Pathway Explained 18:13 Comparative Physiology: Hibernation and Fructose 24:07 Managing Fructose and Health Implications 34:42 Understanding CGM and Glucose Levels 34:54 Factors Affecting Blood Glucose 37:01 The Role of Uric Acid 42:10 Ketones and Inflammation 47:06 Research Insights on BHB and Uric Acid 52:25 Implications for Diet and Health 55:10 Fructose Metabolism and Health 01:01:34 Concluding Thoughts and Future Discussions