From Mushroom to Molecule: Total Synthesis of Ganoapplanin Revealed (3D Visualization) скачать в хорошем качестве

From Mushroom to Molecule: Total Synthesis of Ganoapplanin Revealed (3D Visualization)

Ganoapplanin was first isolated in 2016 from Ganoderma, and the Magauer group achieved the first total synthesis of this amazing structure in 2024. In this video, I explore the structural complexity and provide a step-by-step guide to the total synthesis of this fascinating architecture using 3D animations. I hope you enjoy it. ----------------------------------------------------------------------------------------- Attribution: Vector graphics in this video Designed by Freepik. http://www.freepik.com/ rorozoa - Freepik.com. https://www.freepik.com/free-ai-image... upklyak - Freepik.com. https://www.freepik.com/free-vector/p... starline - Freepik.com. https://www.freepik.com/free-vector/s... ----------------------------------------------------------------------------------------- References: Nicolas Müller, Ondrej ̌ Kovác, Alexander Rode, Daniel Atzl, and Thomas Magauer. J. Am. Chem. Soc. 2024, 146, 33, 22937–22942. https://pubs.acs.org/doi/10.1021/jacs... Exellent review for Stereoelectronic effect: Anomeric effect, hyperconjugation and electrostatics: lessons from complexity in a classic stereoelectronic phenomenon. Chem. Soc. Rev., 2021,50, 10212-10252 https://pubs.rsc.org/en/content/artic... ----------------------------------------------------------------------------------------- Time code: 00:00 - Intro 00:28 - Ganoderma Meroterpenoids 00:59 - Structural Complexity 01:33 - Retrosynthetic Analysis 02:10 - Forward Synthesis 02:17 - Convergent Strategy 02:37 - NHK Reaction 02:51 - 5-exo-trig cyclization 03:19 - Diastereoselectivity 03:38 - Krapcho Reaction 04:36 - Cis Fused System 06:43 - Stereoelectronic effect