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Join Drew and Dr. Dwayne Jackson for an in-depth exploration of why exogenous ketones are experiencing a renaissance - and it has nothing to do with fat loss. Discover cutting-edge mitochondrial peptides, the truth about NAD injections, and how to build the ultimate energy optimization stack without breaking the bank. KEY TAKEAWAYS Why exogenous ketones failed initially and how they're being used correctly now The surprising sleep and HRV benefits of taking ketones before bed SS31 vs other mitochondrial peptides: which delivers the best ROI Methylene blue dosing protocols and dangerous drug interactions to avoid CoQ10, NAD precursors, and PQQ: the affordable alternatives to expensive peptides Why dual-fueling with glucose + ketones is revolutionizing endurance sports EPISODE BREAKDOWN The Ketone Renaissance Dr. Jackson explains why ketones disappeared from the market and what's driving their comeback. The key insight: they're not for fat loss when taken exogenously, but rather provide alternative brain fuel and ATP production, especially during carbohydrate restriction. Bedtime Ketones: The Sleep Game Changer Discover the emerging research on ketones improving sleep latency, REM sleep, and recovery. Drew shares his personal experience tracking HRV improvements with nightly ketone consumption. Dual Fueling for Athletes Learn how endurance athletes are combining glucose and exogenous ketones for sustained energy without GI distress. Dr. Jackson breaks down the physiology of energy system switching during prolonged exercise. Mitochondrial Peptides Deep Dive SS31 (Elamipretide) emerges as the most researched option for mitochondrial health, working by stabilizing electron transport chain complexes and reducing oxidative stress. Compare this to newer options like SLU-PP-332. Methylene Blue Protocols Critical dosing information for methylene blue (0.25-1mg per kg bodyweight) and why higher doses can cause oxidative damage. Plus the serious drug interactions with SSRIs that could cause serotonin syndrome. Budget-Friendly Alternatives CoQ10 (200-400mg ubiquinol), NAD precursors (NR 300mg, NMN 500mg), and PQQ (20-40mg) provide mitochondrial benefits at a fraction of peptide costs. The Foundation First Philosophy Both experts emphasize that no supplement stack can overcome poor lifestyle habits. These advanced protocols only shine when training, diet, recovery, and stress management are already optimized. SAFETY WARNINGS Never combine methylene blue with SSRI/SNRI antidepressants Start with minimal effective doses and increase gradually Cycle peptides during specific training phases (8-16 weeks) Consult healthcare providers before starting any protocol Source quality matters - research suppliers thoroughly Timestamps 00:00 - Introduction & Ketone Overview 02:33 - Ketosis vs Blood Ketone Levels 03:53 - Why Ketone Supplements Lost Popularity 06:21 - Endogenous vs Exogenous Ketones for Fat Loss 07:27 - Optimal Ketone Timing & Applications 09:13 - Ketones for Sleep & Recovery 11:31 - Dual Fueling: Glucose + Ketones for Endurance 15:11 - Ketones for Strength Training & Brain Performance 19:07 - HRV Benefits & Sympathetic vs Parasympathetic States 20:42 - Introduction to Mitochondrial Peptides 23:03 - SS31 (Elamipretide) - Mechanism & Benefits 26:19 - SS31 Applications & Clinical Uses 28:18 - SS31 vs SLU-PP-32 Comparison 31:17 - Methylene Blue - Electron Transport Chain Enhancement 32:29 - Methylene Blue & Oxygen Transport 34:51 - Dosing Protocols for SS31 & Methylene Blue 38:39 - Safety Considerations & Side Effects 40:26 - Over-the-Counter Mitochondrial Supplements 42:50 - CoQ10 for Mitochondrial Support 45:01 - NAD+ Boosters (NR & NMN) 46:31 - NAD Injections vs Oral Precursors 48:10 - NAD Injection Side Effects & Mechanisms 53:34 - PQQ for Mitochondrial Biogenesis 55:27 - Supplement Stacking Strategy 56:01 - Lifestyle Foundation Warning 59:12 - Final Thoughts & Contact Information