Lecture On Pharmacology of Sedatives & Hypnotics: Benzodiazepines, Barbiturates & Z-Drugs | MBBS скачать в хорошем качестве

Lecture On Pharmacology of Sedatives & Hypnotics: Benzodiazepines, Barbiturates & Z-Drugs | MBBS

In this comprehensive pharmacology lecture for the 2024-2025 MBBS batch at Santiniketan Medical College & Hospital, we dive deep into the world of Sedatives and Hypnotics. This session covers the classification, mechanism of action, and clinical applications of central nervous system (CNS) depressants, ranging from traditional barbiturates to modern "Z-drugs." Key Topics Covered: Definitions & Classification: Understanding the transition from "Tranquilizers" to modern Sedatives and Hypnotics [00:36]. Benzodiazepines (BZDs): Mechanism of action as positive allosteric modulators (PAMs) of GABA-A receptors and their clinical preference over barbiturates [03:58, 12:22]. Barbiturates: Why they are largely replaced in clinical practice due to toxicity and a "linear" dose-response curve [05:21, 19:50]. Newer "Z-Drugs": Detailed look at Zolpidem, Zaleplon, and Eszopiclone—their role in short-term insomnia management [05:53, 25:53]. Pharmacokinetics & Lipophilicity: Why high lipid solubility leads to rapid CNS onset and placental/breast milk crossing [07:32, 33:33]. GABA Receptor Heterogeneity: The role of Alpha-1 (sedation), Alpha-2 (anxiolysis), and Alpha-3/5 subunits [22:35, 25:50]. Clinical Emergencies: Using Diazepam and Lorazepam for Status Epilepticus and managing overdose with the competitive antagonist Flumazenil [17:10, 46:51]. Alcohol Withdrawal Management: The clinical use of Chlordiazepoxide in treating withdrawal symptoms [53:24]. SANTINIKETAN MEDICAL COLLEGE & HOSPITAL Real Classroom Demonstration/Lecture On: PHARMACOLOGY by Dr. Analjyoti Ghosh (MBBS Batch: 2024-25) Conducted on: 30-01-26